SCHOOL OF MEDICINE

Department of Medicine

Drug Interactions Flockhart Table ™

This site is dedicated to the memory of a pioneer in clinical pharmacology and pharmacogenetics and the creator of this site/page, Dr. David A. Flockhart, MD, PhD

*Please note it may take several seconds for the table to render completely with all references.

Note: Click on the drug name to view further information. If you're on a Mobile device, please go to the Search area to interact more easily.

Substrates

1A2
 
2B6
 
2C8
 
2C9
 
2C19
 
2D6
 
2E1
 
3A457
 

Inhibitors

Inhibitors compete with other drugs for a particular enzyme thus affecting the optimal level of metabolism of the substrate drug which in many cases affect the individual's response to that particular medication, e.g. making it ineffective.

red A Strong inhibitor is one that causes a ≥ 5-fold increase in the plasma AUC values or more than 80% decrease in clearance.
orange A Moderate inhibitor is one that causes a 2 fold to < 5-fold increase in the plasma AUC values or 50-80% decrease in clearance.
green A Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold increase in the plasma AUC values or 20-50% decrease in clearance.
A In-Vitro Only In-Vitro Only Inhibitor strength.
TBD Inhibitor strength level is under review.

1A2
 
2B6
 
2C8
 
2C9
 
2C19
 
2D6
 
2E1
 
3A457
 

Inducers

1A2
 
2B6
 
2C8
 
2C9
 
2C19
 
2D6 2E1
 
3A457
 

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Clinical Pharmacology

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