Drug Interactions Pocket Reference Card


P450 Drug Interaction Pocket Cards are no longer being sold . A mobile application is being developed that we hope will make this information easily accessible and convenient to use. Anticipated release is Summer 2021. Check back soon for more information or contact Christine McDonald (chrimcdo@iu.edu) to be notified when the app is available.



Why did we create the P450 card?

The effective, intelligent management of many problems related to drug interactions in clinical prescribing can be helped by an understanding of how drugs are metabolized. Specifically, if a prescriber is aware of the dominant cytochrome P450 isoform involved in a drug's metabolism, it is possible to anticipate, from the inhibitor and inducer lists for that enzyme, which drugs might cause significant interactions. The laminated card table is focused on clinically relevant interactions, and is updated at least twice yearly.

What does the card contain?

The P450 Drug Interactions Card contains a table with eight (8) columns, one for each of the P450 isoform groups: CYP1A2, etc. In each column you will find:

  • Substrates: drugs that are metabolized as substrates by the enzyme
  • Inhibitors: drugs that prevent the enzyme from metabolizing the substrates
  • Activators: drugs that increase the enzyme's ability to metabolize the substrates

For more information:

Business Administrator
Christine McDonald
chrimcdo@iu.edu