Drug Interactions Flockhart Table ™

This site is dedicated to the memory of a pioneer in clinical pharmacology and pharmacogenetics and the creator of this site/page, Dr. David A. Flockhart, MD, PhD

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Substrates

Substrates: drugs metabolized by the enzyme.

Color-Coded System: indicates the strength of evidence from literature evaluating the drug as a substrate for specific enzyme.

red Strong Evidence: the enzyme is majorly responsible for drug metabolism.
orange Moderate Evidence: the enzyme plays a significant but not exclusive role in drug metabolism or the supporting literature is not extensive.
green Weak Evidence: the enzyme plays minor role in drug metabolism or the available literature is limited.
In-Vitro Evidence: evidence is based solely on in vitro studies.
TBD: the strength of evidence is under review.

1A2
 
2B6
 
2C8
 
2C9
 
2C19
 
2D6